Parameters

Dapsone

BCG

Treatment groups

RPMP

DBR

MIX

AUC(0 − t) (mg* h/l)

49.54 ± 14.73

12.66 ± 4.12^**▲▲

27.41 ± 5.76^**

33.80 ± 6.43^*

AUC(0 − ∞) (mg* h/l)

83.28 ± 18.19

13.31 ± 4.64^**▲▲

52.64 ± 13.06^*

43.86 ± 5.66^*

MRT(0 − t) (h)

4.01 ± 0.45

1.46 ± 0.79^**▲▲

4.40 ± 0.40

4.02 ± 0.26

MRT(0 −∞) (h)

12.20 ± 9.46

2.06 ± 1.28^**▲▲

17.46 ± 8.43^▲▲

8.51 ± 3.39

t_1/2 (h)

9.14 ± 2.15

2.67 ± 0.71^**▲

6.12 ± 1.90^*

6.73 ± 0.73^*

CL (l/h/kg)

0.16 ± 0.085

0.32 ± 0.043^**▲

0.24 ± 0.055^*

0.26 ± 0.032^*

Vz (L/Kg)

1.48 ± 0.39

3.55 ± 0.57^**

3.52 ± 0.93^**▲

2.21 ± 0.80^*